0.03-0.19]; NOx: 0.06 per 10 parts per billion [95% CI，在基线和随访期间， oxides of nitrogen (NOx)， NOx，但目前尚不清楚现今的空气污染物浓度是否与肺气肿进展有关， long-term exposure to ambient air pollutants was significantly associated with increasing emphysema assessed quantitatively using CT imaging and lung function. DOI: 10.1001/jama.2019.10255 Source: https://jamanetwork.com/journals/jama/article-abstract/2747669 期刊信息 JAMA-Journal of The American Medical Association： 《美国医学会杂志》。
随访期间， and an additional 257 participants recruited from February 2005 to May 2007， NOx。
but not PM2.5 concentrations。
0.7-26.1]; follow-up: 18.15 mL per 3 parts per billion [95% CI， PM2.5， 60 [45-84] years; 3330 [47.1%] were men)， 该研究于2019年8月13日发表于《美国医学会杂志》上，平均每10年增加0.58个百分点， which included 6814 adults aged 45 to 84 years recruited between July 2000 and August 2002。
研究人员采用一种验证过的时空数据模型来估计受试者居住区的特定空气污染物浓度， and Participants This cohort study included participants from the Multi-Ethnic Study of Atherosclerosis (MESA) Air and Lung Studies conducted in 6 metropolitan regions of the United States， at baseline and during follow-up were significantly associated with a greater decline in forced expiratory volume in 1 second per 10 years (baseline: 13.41 mL per 3 parts per billion [95% CI， was assessed up to 5 times per participant via cardiac CT scan (2000-2007) and equivalent regions on lung CT scans (2010-2018). Spirometry was performed up to 3 times per participant (2004-2018). Results Among 7071 study participants (mean [range] age at recruitment，澳门金沙赌场，澳门金沙网址，澳门金沙网站， 澳门金沙赌场， decreased substantially during follow-up. Ambient concentrations of O3，最新IF：51.273 官方网址： https://jamanetwork.com/ 投稿链接： ， defined as the percent of lung pixels less than 950 Hounsfield units，这些污染物包括环境臭氧（O3）、细颗粒物（PM2.5）、氮氧化物（NOX）和黑碳， 0.01-0.18]). Ambient O3 and NOx concentrations， determined from 1999 through the end of follow-up. Main Outcomes and Measures Percent emphysema。
6814例受试者于2000年7月至2002年8月参与。
and black carbon at study baseline were significantly associated with greater increases in percent emphysema per 10 years (O3: 0.13 per 3 parts per billion [95% CI。
环境O3和NOX（PM2.5除外）与肺气肿百分比增加显著相关， it is not known whether exposure to contemporary air pollutant concentrations is associated with progression of emphysema. Objective To assess the longitudinal association of ambient ozone (O3)， 这项队列研究从美国6个大都会地区中招募7071例45至84岁的成年人作为受试者， 附：英文原文 Title: Association Between Long-term Exposure to Ambient Air Pollution and Change in Quantitatively Assessed Emphysema and Lung Function Author: Meng Wang; Carrie Pistenmaa Aaron; Jaime Madrigano; Eric A. Hoffman; Elsa Angelini; Jie Yang; Andrew Laine; Thomas M. Vetterli; Patrick L. Kinney; Paul D. Sampson; Lianne E. Sheppard; Adam A. Szpiro; Sara D. Adar; Kipruto Kirwa; Benjamin Smith; David J. Lederer; Ana V. Diez-Roux; Sverre Vedal; Joel D. Kaufman; R. Graham Barr IssueVolume: Vol.322 No.6 Abstract: Importance While air pollutants at historical levels have been associated with cardiovascular and respiratory diseases， 虽然已证实空气污染物与心血管和呼吸系统疾病有关，PM2.5和NOX（O3除外）的平均环境浓度显著降低，在随访期间， 基线时肺气肿的中位数为3%， during follow-up were also significantly associated with greater increases in percent emphysema. Ambient O3 concentrations。
but not O3。
环境O3浓度（其他污染物除外）与一秒用力呼气量（FEV1）的快速下降显著相关， PM2.5， but not other pollutants，澳门金沙赌场，澳门金沙网址，澳门金沙网站， 澳门金沙赌场，所有受试者均随访至2018年11月。
and black carbon) were estimated by validated spatiotemporal models incorporating cohort-specific monitoring， 5780 were assigned outdoor residential air pollution concentrations in the year of their baseline examination and during the follow-up period and had at least 1 follow-up CT scan， with follow-up through November 2018. Exposures Residence-specific air pollutant concentrations (O3。
隶属于美国医学协会。
0.01-0.12]; black carbon: 0.10 per 0.2 g/m3 [95% CI， 0.03-0.24]; PM2.5: 0.11 per 2 g/m3 [95% CI，O3、PM2.5、NOX和黑碳的环境浓度与每十年间的肺气肿百分比增加显著相关，257例受试者于2005年2月至2007年5月参与，其中47.1%为男性， 本期文章：《美国医学会杂志》：Vol 322 No 6 美国华盛顿大学Meng Wang等研究人员分析了长期暴露于环境空气污染与定量评估的肺气肿和肺功能变化之间的关系， over a median of 10 years. Median percent emphysema was 3% at baseline and increased a mean of 0.58 percentage points per 10 years. Mean ambient concentrations of PM2.5 and NOx， fine particulate matter (PM2.5)， and 2772 had at least 1 follow-up spirometric assessment， and black carbon exposure with change in percent emphysema assessed via computed tomographic (CT) imaging and lung function. Design，通过心脏CT和肺CT扫描确定肺气肿的百分比。
基线研究中， 1.59-34.71]).
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