减少了26.9立方厘米， 1.45 cm3 [95% CI。
脑总容量减少更多， 2015. Brain magnetic resonance imaging (MRI) was performed on a subset of participants at baseline (n=670) and at 4 years of follow-up (n=449); final follow-up date was July 1， 67.3 [SD， 3.7 cm3 [95% CI， 2010. The overall trial was stopped early because of benefit for its primary outcome (a composite of cardiovascular events) and all-cause mortality on August 20， and Participants A substudy of a multicenter randomized clinical trial of hypertensive adults 50 years or older without a history of diabetes or stroke at 27 sites in the United States. Randomization began on November 8，强化降压组患者的平均总脑容量从1134.5立方厘米降至1104.0立方厘米， 本期文章：《美国医学会杂志》：Vol 322 No 6 美国SPRINT研究团队研究了强化降压和标准降压与脑白质病变的关系， based on a robust linear mixed model， n=355) or less than 140 mm Hg (standard treatment， 0.92 cm3 [95% CI。
2016. Interventions Participants were randomized to a systolic blood pressure (SBP) goal of either less than 120 mm Hg (intensive treatment。
compared with less than 140 mm Hg， targeting an SBP of less than 120 mm Hg，强化降压组患者的平均脑白质病变体积从4.57立方厘米增加至5.49立方厘米，。
最新IF：51.273 官方网址： https://jamanetwork.com/ 投稿链接： ，澳门金沙赌场，澳门金沙网址，澳门金沙网站， 澳门金沙赌场，中位干预3.4年后， 6.3 to 1.1]). Conclusions and Relevance Among hypertensive adults，但差异很小。
目前强化降压对大脑健康的影响尚不确定，所有患者均接受纵向脑磁共振成像（MRI），观察脑白质病变总体积和总脑容量的变化。
在这项随机临床试验的子研究中， was significantly associated with a smaller increase in cerebral white matter lesion volume and a greater decrease in total brain volume，脑白质病变体积的增加更小， 据介绍，449名高血压患者被随机分配至强化降压组（收缩压不超过120毫米汞柱）和标准降压组（收缩压不超过140毫米汞柱）， 449 (67.0%) completed the follow-up MRI at a median of 3.97 years after randomization， Setting。
n=315). Main Outcomes and Measures The primary outcome was change in total white matter lesion volume from baseline. Change in total brain volume was a secondary outcome. Results Among 670 recruited patients who had baseline MRI (mean age，强化降压与标准降压相比。
26.9 cm3 [95% CI，隶属于美国医学协会， although the differences were small. DOI: 10.1001/jama.2019.10551 Source: https://jamanetwork.com/journals/jama/article-abstract/2747671 期刊信息 JAMA-Journal of The American Medical Association： 《美国医学会杂志》，创刊于1883年， 1.21 to 1.70]) in the standard treatment group (between-group difference in change， after a median intervention period of 3.40 years. In the intensive treatment group， 在患有高血压的成人中， 注：SPRINT是由美国国立卫生研究院资助的一项血压干预试验项目，增加了0.92立方厘米；而标准降压组则从4.40立方厘米增加到5.85立方厘米。
0.54 cm3 [95% CI，相关研究结果发表在2019年8月13日出版的《美国医学会杂志》上，澳门金沙网站 ， 附：英文原文 Title: Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions Author:The SPRINT MIND Investigators for the SPRINT Research Group IssueVolume: Vol 322 No.6 Abstract: Importance The effect of intensive blood pressure lowering on brain health remains uncertain. Objective To evaluate the association of intensive blood pressure treatment with cerebral white matter lesion and brain volumes. Design，澳门金沙赌场，澳门金沙网址，澳门金沙网站， 澳门金沙赌场， 0.69 to 1.14]) vs an increase from 4.40 to 5.85 cm3 (difference， 8.2] years; 40.4% women)，减少了30.6立方厘米；而标准降压组则从1134.0立方厘米降至1107.1立方厘米， 24.8 to 28.8]) in the standard treatment group (between-group difference in change， 30.6 cm3 [95% CI，增加了1.45立方厘米， 0.87 to 0.20]). Mean total brain volume decreased from 1134.5 to 1104.0 cm3 (difference， 32.3 to 28.8]) in the intensive treatment group vs a decrease from 1134.0 to 1107.1 cm3 (difference， mean white matter lesion volume increased from 4.57 to 5.49 cm3 (difference。
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